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Autofluorescence and microperimetry in clinically significant diabetic macular edema
Author(s) -
BOTTEGA E,
VUJOSEVIC S,
PILOTTO E,
BENETTI E,
CASCIANO M,
MIDENA E
Publication year - 2008
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2008.4412.x
Subject(s) - microperimetry , medicine , ophthalmology , macular edema , fundus (uterus) , retinal , fluorescein angiography , visual acuity , diabetic retinopathy , diabetes mellitus , endocrinology
Purpose Clinically significant diabetic macular edema (CSME) shows variable retinal structural and functional impairment. The aim of this study was to assess the correlation between different macular parameters, mainly fundus autofluorescence (FAF) and macular sensitivity, in diabetics with CSME. Methods Sixty diabetic patients with untreated CSME (104 eyes) underwent: best corrected visual acuity determination (BCVA, logMAR), slit lamp biomicroscopy, fluorescein angiography, OCT, FAF and microperimetry. Results Thirty eyes had normal FAF , whereas 74 increased (IFAF) pattern. Retinal sensitivity over areas with IFAF was significantly lower than over areas with normal FAF (p<0.001). Cystoid OCT‐pattern correlated to both presence and dimension of IFAF (p<0.05), whereas sponge‐like and subfoveal neuroretinal detachment did not. BCVA did not correlate either to FAF pattern or area of IFAF. Conclusion Functional impact of CSME correlate with IFAF and is better determined with macular microperimetry rather than VA. Increased FAF seems to be a relevant characteristic of cystoid CSME. New structural and functional parameters should be used to better predict the prognosis of (treated and untreated) eyes affected by CSME.