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Macrophage modulation of inflammatory responses
Author(s) -
DICK AD
Publication year - 2008
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2008.3316.x-i1
Subject(s) - macrophage , immune system , chemokine , biology , inflammation , retina , neuroscience , homeostasis , microbiology and biotechnology , immunology , genetics , in vitro
Purpose To give overview of the role of myeloid cells in homeostasis and more particularly their role in generating tissue damage as well as regulating immune responses within the retina. Methods Reviewing the experimental evidence of homeostatic role of macrophage populations in the iris, choroid and retina of normal eye we will focus on the behviour and mechanisms of tissue damage during experimental autoinflammatory responses. In particular examining the interaction of myeloid cells in controlling inflamamtory responses during acute and regulatory phases (resolution) of disease. Results The overall plasticity of macrophage populations and their intrinsic ability to respond to microenviromental signals (cytokines, chemokines and cognate receptor signalling) allows rapid responses to initiate yet limit tissue damage and generates targets to manipulate toward therapeutic gain.Commercial interest