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Retinal artery occlusion following intravitreal anti‐VEGF therapy
Author(s) -
Von Hanno Therese,
Kinge Bettina,
Fossen Kristian
Publication year - 2010
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2008.01406.x
Subject(s) - medicine , ranibizumab , ophthalmology , macular degeneration , retinal , central retinal vein occlusion , visual acuity , occlusion , bevacizumab , central retinal artery occlusion , central retinal artery , central retinal vein , retinal vein , branch retinal vein occlusion , retina , surgery , macular edema , chemotherapy , physics , optics
. Purpose: Anti‐vascular endothelial growth factor (anti‐VEGF) therapy effectively inhibits angiogenesis and is now enjoying widespread use in the treatment of age‐related macular degeneration (AMD). It may also have a role in the treatment of macular oedema secondary to other conditions. VEGF is a signalling molecule that has a variety of roles, including vasoregulation and effects on the coagulation homeostasis. Anti‐VEGF therapy may therefore have adverse effects on ocular blood flow. Methods: Two cases of retinal artery occlusion after intravitreal injection of anti‐VEGF are presented. Both patients were given the treatment to reduce macular oedema secondary to central retinal vein occlusion. Possible mechanisms are discussed. Results: Patient 1 developed a central retinal artery occlusion within 1 month of an intravitreal injection of ranibizumab (Lucentis ® ). The macular oedema was totally resolved at 1 month; final visual acuity (VA) was light perception. Patient 2 developed a branch retinal artery occlusion in the macula 2 days after an intravitreal injection of bevacizumab (Avastin ® ). The macular oedema was almost resolved within 1 week and did not recur; final VA was 0.6. Conclusions: Anti‐VEGF therapy may have a role in the treatment of macular oedema caused by central retinal vein occlusions. However, our report indicates that the therapeutic principle may be associated with an increased risk of retinal arterial occlusions.