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Macular microcirculation in hypertensive patients with and without branch retinal vein occlusion
Author(s) -
Noma Hidetaka,
Funatsu Hideharu,
Sakata Kumi,
Harino Seiyo,
Mimura Tatsuya,
Hori Sadao
Publication year - 2009
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2008.01318.x
Subject(s) - branch retinal vein occlusion , medicine , microcirculation , pathogenesis , ophthalmology , logistic regression , retinal , fluorescein angiography , occlusion , retinopathy , cardiology , diabetes mellitus , macular edema , endocrinology
. Purpose: Our purpose was to determine whether a reduction in blood flow velocity (BFV) in the perifoveal capillaries is involved in the pathogenesis of branch retinal vein occlusion (BRVO) in patients with hypertension. Methods: Subjects included hypertensive patients with ( n = 12) and without ( n = 16) BRVO and healthy volunteers ( n = 16). Perifoveal BFV was measured by the tracing method using fluorescein angiography and a scanning laser ophthalmoscope. Logistic regression analysis was performed to assess factors that influenced the presence or absence of BRVO. Results: Mean BFV showed a significant decrease across the three groups (healthy controls: 1.49 ± 0.11 mm/second; hypertensive patients without BRVO: 1.36 ± 0.12 mm/second; hypertensive patients with BRVO: 1.16 ± 0.24 mm/second; p trend < 0.001). Multivariate logistic regression analysis showed that BFV was a significant risk factor for the presence of BRVO. Conclusions: Perifoveal capillary BFV is reduced in hypertensive patients with and without BRVO. It is possible that a decrease in BFV may be involved in the occurrence of BRVO. Measurement of perifoveal capillary BFV may be useful for investigating the pathogenesis and progression of BRVO.