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Wound healing and myopic regression following photorefractive keratectomy
Author(s) -
Fagerholm Per,
HambergNyström Helene,
Tengroth Björn
Publication year - 1994
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1994.tb05021.x
Subject(s) - photorefractive keratectomy , ophthalmology , medicine , optometry , wound healing , cornea , surgery
Scrapings from the treated area of 17 patients who had undergone photorefractive keratectomy were analyzed. All patients had regressed to myopia and were scraped at the time of retreatment. Three scrapings from the epithelium of patients undergoing primary photorefractive keratectomy served as control. Formalin fixed and paraffin embedded, the specimens were sectioned and stained specifically for hyaluronic acid. Hematoxylin was used for counterstaining in all specimens. Scrapings revealed either epithelial hyperplasia (11 cases) or an increased amount of extracellular material (15 cases) or both (9 cases). Five of the specimens stained positive for hyaluronic acid. Four of these cases showed the highest degree of corneal haze. The latter suggests a role for hyaluronic acid formation in excessive wound healing, causing myopic regression. All patients had received prolonged topical steroid treatment, a measure that may suppress a normal occurrence of hyaluronic acid.