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Herpes simplex virus type 2 induced retinal necrosis in BALB/c mice
Author(s) -
Zierhut Manfred,
Hemady Ramzi,
Zhao TongZhen,
Merchant Amyna,
Foster C. Stephen
Publication year - 1994
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1994.tb05018.x
Subject(s) - herpes simplex virus , retinitis , virus , acute retinal necrosis , virology , encephalitis , herpesviridae , titer , medicine , viral disease , human cytomegalovirus
We injected herpes simplex virus type 2 of MS‐ or G‐strain into the anterior chamber of BALB/c mice. In the contralateral eye inflammatory cell infiltration began in the ciliary body; focal retinitis, detected by day 8, led to total destruction of the retina by day 10. Contralateral disease was observed in 75% of mice inoculated with 8 times 10 3 pfu herpes simplex virus type 2, but in only 20% of mice receiving 80 pfu herpes simplex virus type 2. Still this low concentration, however, produced a suppressed delayed‐type hypersensitivity response. Anti‐herpes simplex virus type 2 antiboy, first detected on day 8, reached hight titers on day 10; by then, most of the mice had died of encephalitis. The G‐strain of herpes simplex virus type 2 was more neurotoxic than the MS‐strain, but produced the same incidence of contralateral retinitis. Herpes simplex virus type 2 produces contralateral necrotizing retinitis comparable to that produced by herpes simplex virus type 1. These findings, like those of other authors, suggest a role for herpes simplex virus type 2 in some cases of acute retinal necrosis in humans.