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Impaired contrast sensitivity in adolescents and young Type 1 (insulin‐dependent) diabetic patients with microalbuminuria
Author(s) -
Bangstad H.J.,
BrinchmannHansen O.,
Hultgren S.,
DahlJørgensen K.,
Hanssen K. F.
Publication year - 1994
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1994.tb04677.x
Subject(s) - microalbuminuria , medicine , diabetic retinopathy , retinopathy , visual acuity , ophthalmology , diabetes mellitus , type 2 diabetes , contrast (vision) , fundus photography , ophthalmoscopy , fundus (uterus) , fluorescein angiography , endocrinology , retinal , artificial intelligence , computer science
. We compared neurosensorial visual function by psychophysical tests (macular recovery time and contrast sensitivity) in two well matched groups of young Type 1 (insulin‐dependent) diabetic patients with micro‐and normoalbuminuria, respectively. The patients had normal visual acuity (≥ 1.0) and either no retinopathy or non‐proliferative retinopathy. Thirty patients with microalbuminuria (albumin excretion ≥ 15 μg/min in a least two out of three timed overnight urine samples) were matched (age, diabetes duration, mean one‐year HbA 1c , gender) with normoalbuminuric (n = 27) patients. Retinopathy (50° colour fundus photography) was assessed by counting microaneurysms and hemorrhages as ‘red spots’. Contrast sensitivity was examined for the spatial frequencies of 1.5, 3, 6, 12 and 18 cycles per degree (cpd). Macular recovery time (nyctometry) refers to the time‐related (2 min) ability of the retina to regain visual acuity following exposure to bright light (photostress). Contrast sensitivity score was reduced in patients with microalbuminuria compared to those without; 18 cpd (mean and 95% confidence intervals): [4.2 (3.8‐4.7) vs 5.0 (4.6‐5.4), p = 0.03]. Macular recovery performance was not significantly reduced: [21.0 arbitrary units (17.5–24.6) vs 26.0 (22.6–30.7), p = 0.12]. We conclude that impaired contrast sensitivity independent of background retinopathy is shown in a group of young Type 1 (insulin‐dependent) diabetic patients with low‐grade microalbuminuria compared to a group of patients with normoalbuminuria.