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Intra‐operative use of 5‐Fluorouracil in glaucoma filtering surgery
Author(s) -
Cunliffe I. A.,
Longstaff S.
Publication year - 1993
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1993.tb08593.x
Subject(s) - medicine , trabeculectomy , sclera , antimetabolite , glaucoma , intraocular pressure , fluorouracil , surgery , mitomycin c , glaucoma surgery , ophthalmology , chemotherapy
. This study reviews the otucome of 14 eyes considered to be at risk of surgical failure undergoing trabeculectomy with 5‐Fluorouracil (5‐FU). The antimetabolite was administered intra‐operatively by placing a surgical sponge soaked in 5‐FU (25 mg/ml) directly on the sclera under the conjunctival flap for 5 minutes. All eyes showed a reduction in intraocular pressure (IOP) at a mean follow‐up of 18.5 weeks, and only one eye required topical antiglaucoma medication. Mean IOP reduction at final follow‐up was 43.1%. No eyes showed any corneal problems associated with the intra‐operative use of 5‐FU. These results suggest that the intra‐operative use of 5‐Fluorouracil is an effective way of improving surgical success in at risk eyes. The early complications appear to be less than those associated with post‐operative subconjunctival injections of 5‐FU, but the long‐term differences are still to be shown.