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Retinal cone dysfunction of supernormal rod ERG type
Author(s) -
Rosenberg Thomas,
Simonsen Svend Erik
Publication year - 1993
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1993.tb04998.x
Subject(s) - erg , ophthalmology , retinal , medicine , retina , electroretinography , cone (formal languages) , anatomy , neuroscience , biology , computer science , algorithm
Five patients, not related to each other, showed clinical signs, including electroretinograms, of a retinal dysfunction which mainly affected die cone system, but also involved the rod responses in a peculiar way. ERG b‐wave threshold under dark adapted conditions was elevated. In contrast, rod b‐wave sensitivity was enhanced with medium to high intensity flash stimulation. Furthermore, all patients had a severe reduction of the oscillatory potentials. The findings are discussed with special emphasis on a hypothetical disturbance in the cyclic guanosine monophosphate metabolism, involving both photoreceptors and cells of the inner plexiform layer responsible for retinal feedback mechanisms.