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Early effects of sodium iodate injection on ERG in mice
Author(s) -
Hosoda Liliana,
AdachiUsami Emiko,
Mizota Atsushi,
Hanawa Tadao,
Kimura Tsuyoshi
Publication year - 1993
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1993.tb04650.x
Subject(s) - erg , iodate , sodium , ophthalmology , chemistry , medicine , iodine , retinal , organic chemistry
. The electroretinogram (ERG) was recorded in 15 ICR albino mice before and 2, 4 and 24 h after injection of 40 mg/kg of NaIO 3 and the results were compared with the corresponding ultrastructural findings. Both a‐ and b‐wave amplitudes decreased at 2 h after injection and increased at 4 h to the levels before injection and further increased at 24 h after injection. The b‐wave threshold intensity increased by 2.1 log units at 2 h after injection. Thereafter, it decreased once at 4 h and significantly increased at 24 h by 3.4 log units. Electron microscopic examination showed swollen cytoplasmic organelles of the retinal pigment epithelial cells at 4 h after injection. It was thus demonstrated that an early effect of NaIO 3 on the electrical response of the mouse retina was more conspicuous than histopathological changes.