The association between HLA B5 and ocular involvement in Behçet's disease in southern Turkey | Zendy

Soylu Merih | Zendy; Ersöz T. Reha | Zendy; Erken Eren | Zendy

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The association between HLA B5 and ocular involvement in Behçet's disease in southern Turkey

Author(s) -

Soylu Merih,

Ersöz T. Reha,

Erken Eren

Publication year - 1992

Publication title -

acta ophthalmologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.534

H-Index - 87

eISSN - 1755-3768

pISSN - 1755-375X

DOI - 10.1111/j.1755-3768.1992.tb04888.x

Subject(s) - behcet's disease , etiology , human leukocyte antigen , disease , medicine , uveitis , genetic predisposition , immunology , dermatology , antigen , pathology

HLA B5 plays an important role in the aetiology of Behçet's disease. The frequency of HLA B5 differs between racial groups and geographical regions. Ocular involvement, which could lead to serious complications, is a very important feature of Behçet's disease. Various racial groups having different genetic properties live in the Čukurova region, located in southern Turkey. To investigate the role of HLA B5 in Behçet's disease in Čukurova region, HLA B5 antigens were investigated by lymphocytotoxicity assay in 65 patients and 200 healthy controls. A significantly higher frequency was found in the patient group. Neither ocular involvement, nor the type of uveitis showed any correlation with HLA B5, but it was found that patients presenting with frequent ocular attacks had significantly higher HLA B5 positivity than the patients with rare attacks. This observation suggests that HLA B5 would be a negative factor in visual prognosis in Behçet's disease.

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