Premium
Gentamicin, norfloxacin and lysozyme concentration in human tears: in vivo and in vitro study
Author(s) -
Bron A. M.,
Bonnin C.,
Garcher C.,
Lallemand A.
Publication year - 1992
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1992.tb04881.x
Subject(s) - norfloxacin , gentamicin , lysozyme , in vivo , in vitro , tears , pharmacology , chemistry , antibiotics , medicine , biology , immunology , biochemistry , ciprofloxacin , microbiology and biotechnology
Hen's egg lysozyme (HEL) activity was measured in vitro with gentamicin and norfloxacin by a turbidimetric technique. Gentamicin at the concentration of 10 ‐3 M inhibited HEL activity by 39%, while 10 ‐3 M norfloxacin did not affect HEL activity. However, an in vivo study in healthy persons did not show any significant statistical difference in tear lysozyme activity when 0.3% gentamicin or 0.3% norfloxacin were topically applied.