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INTEGRINS AS RECEPTORS FOR EXTRACELLULAR MATRIX PROTEINS IN HUMAN CORNEA
Author(s) -
Virtanen Ismo,
Tervo Kaarina,
Korhonen Matti,
Päällysaho Taru,
Tervo Timo
Publication year - 1992
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1992.tb02163.x
Subject(s) - integrin , extracellular matrix , microbiology and biotechnology , basement membrane , glycoprotein , receptor , cell surface receptor , alpha (finance) , biology , cell type , membrane glycoproteins , collagen receptor , beta (programming language) , membrane protein , cell , membrane , biochemistry , medicine , construct validity , nursing , computer science , patient satisfaction , programming language
Extracellular matrix (ECM) proteins form distinct proteinfamilies that play a role during tissue maturation, wound healing and maintenance of tissue architecture. Recent studies show that there are tissue type ‐specific variations in their expression. ECM proteins function by complexing with each other and also by interacting with their cellular receptors, called integrins. Integrins are heterodimeric membrane. glycoproteins that are partly cell type ‐specifically expressed in human tissues. Like other stratified epithelia, corneal epithelium expresses α 2 β 1 , α 3 β 1 , α 6 β 1,4 , and α v β 1 integrins that mediate attachment to the basement membrane and cell‐cell interactions.