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MOLECULAR AND CELLULAR RESPONSES OF THE CORNEAL EPITHELIUM TO WOUND HEALING
Author(s) -
Beuerman Roger W.,
Thompson Hilary W.
Publication year - 1992
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1992.tb02161.x
Subject(s) - corneal epithelium , wound healing , microbiology and biotechnology , mitosis , epithelium , biology , cornea , population , cell , cell growth , downregulation and upregulation , receptor , immunology , medicine , gene , neuroscience , genetics , environmental health
The corneal epithelium responds rapidly to injury, repairing defects with a layer of cells that covers the denuded corneal surface and prevents infection and loss of vision. After a wound, reorganization of the remaining epithelial cells occurs over several hours, resulting in the formation of a migratory leading edge. However, expression of genes such as c‐ fos occurs within minutes of wounding. This early expression may be important for directing epithelial reorganization and the later mitotic burst. Our results show that receptors for epidermal growth factor are upregulated in the migratory cell population. Proliferation through a mitotic burst was observed in cells surrounding the original wound margin after 36 hours. The interaction between gene expression and cell surface receptors for growth factors and cell proliferation suggests that wound healing occurs in a complex, but tightly controlled process in the corneal epithelium.