Premium
The effect of indomethacin 1% ophthalmic suspension on the pupil during extracapsular cataract surgery
Author(s) -
Gregersen Per Lykke,
Nielsen Per Julius,
Mortensen Kelvin Kamp
Publication year - 1992
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1992.tb02124.x
Subject(s) - medicine , miosis , capsulotomy , pupil , cataract surgery , ophthalmology , intraocular lens , surgery , lens (geology) , pupillary response , anesthesia , neuroscience , biology , petroleum engineering , engineering
Fifty‐six patients who underwent extracapsular cataract surgery were randomized in two groups with 28 patients in each group. Group 1 was treated with standard preoperative dilation regime and group 2 received in addition indomethacin 1% ophthalmic solution. Horizontal and vertical pupil diameter measurements were taken before capsulotomy, before exprimation of the lens nucleus and before lens implantation. The size of the pupil at the time of capsulotomy and at the time just before lens exprimation was greatest in the non‐indomethacin treated group, but at the time of lens implantation the pupil of the indomethacin treated group was greatest. It is concluded that even though indomethacin seems to be able to inhibit surgically induced miosis, probably through its inhibitory effect on prostaglandine synthesis, the effect is only marginal and from a clinical point of view it cannot be recommended.