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Image analysis of changes in drusen area
Author(s) -
Sebag Mikael,
Peli Eli,
Lahav Moshe
Publication year - 1991
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1991.tb04847.x
Subject(s) - drusen , fundus (uterus) , ophthalmology , medicine , macular degeneration , optometry
Computerized image processing was used to analyze color fundus photographs of 11 patients (22 eyes) with macular drusen who were followed for more than 2 years (mean follow‐up, 4.7 years). Significant changes over time (more than ± 20% of baseline area) were measured in the surface area of macular drusen in 18 of 22 (82%) eyes. An increase in the drusen area was associated significantly with eyes with mostly hard drusen and an initially smaller drusen area; but a decrease was associated with eyes with mostly soft drusen and an initially larger drusen area ( P <0.01). The mean absolute rate of change in the drusen area was more than twice as great in eyes with mostly soft drusen compared with those with mostly hard drusen ( P <0.05). All eye pairs studied showed a concomitant increase or decrease in the drusen area.