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Topical Indometacin, a prostaglandin inhibitor, in acute anterior uveitis. A controlled clinical trial of non‐steroid versus steroid anti‐inflammatory treatment
Author(s) -
Sand B. B.,
Krogh E.
Publication year - 1991
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1991.tb02703.x
Subject(s) - indometacin , medicine , steroid , topical steroid , randomized controlled trial , adverse effect , uveitis , significant difference , prostaglandin , anesthesia , gastroenterology , pharmacology , dermatology , ophthalmology , chemistry , enzyme inhibitor , hormone , prostaglandin endoperoxide synthase , biochemistry , in vitro
. Fortynine patients were included in a controlled clinical trial comparing the effect of topical nonsteroid versus potent steroid preparation in acute anterior non‐granulomatous uveitis. Twentyfive patients were randomized to 1% Indometacin and 24 patients to 0.1% Dexametason treatment 6 times a day. There was no difference between the two groups initially. After 7 days of treatment we found significantly less inflammation in the steroid treated group, this significant difference disappearing on day 14. We conclude that whenever adverse reactions to corticosteroid eye drops are suspected or proven, Indometacin eye drops make up a useful alternative to even strong solutions of steroids. The study was carried out in the following practices: L. Ahrendt, L. Damgård‐Jensen, P. Eldrup‐Jørgensen, J. Elmeros, H. Heuer, S. Jensen, M. H. Kjeldsen, P. Nellemann Sørensen, H. Petersen, N. Vedel‐Jensen.