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Ocular irritation leads to the appearance of proteolytic activity in the aqueous humor
Author(s) -
Tervo Timo,
Setten GysbertBotho,
Joutsimo Laila,
Tarkkanen Ahti,
Tervo Kaarina
Publication year - 1991
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1991.tb02039.x
Subject(s) - irritation , aqueous humor , chemistry , ophthalmology , iris (biosensor) , medicine , immunology , computer security , computer science , biometrics
Aqueous humor (AH) collected from healthy eyes of man and rabbit was analysed for proteolytic activity using a casein‐agar assay. Normal AH collected during surgery or rabbit AH aspirated before ocular irritation contained no caseinolytic activity. In rabbits, mechanical irritation of the iris and subconjunctival as well as intra‐cameral injection of capsaicin led to ocular irritative response. AH samples collected after such manipulation contained a considerable caseinolytic activity. On the other hand, anterior chamber puncture alone did not seem to induce elevation of caseinolytic activity in AH. The clinical significance of this phenomenon and the mechanisms behind it are discussed.