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Iris vasculopathy in exfoliation syndrome
Author(s) -
Konstas A. G. P.,
Marshall G. E.,
Lee W. R.
Publication year - 1991
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1991.tb02025.x
Subject(s) - laminin , iris (biosensor) , iridectomy , pathology , exfoliation joint , matrix (chemical analysis) , anatomy , chemistry , medicine , extracellular matrix , materials science , biochemistry , graphene , alternative medicine , computer security , chromatography , computer science , biometrics , nanotechnology
Samples of control iris tissue obtained from seven enucleated eyes and nine exfoliative iridectomy specimens were prepared for an immunocytochemical study of the matrix in the walls of iris vessels. The distribution of collagen types I, IV and laminin was studied in normal and exfoliative vessels. Laminin was an integral component of exfoliation material and was present mainly in the matrix of the outer surface of normal vascular cohort cells. The laminin content in the latter location was reduced in vessels in which exfoliation aggregates were not visible. Collagen type IV was absent from exfoliation material. While type I was present in the deposits, it was considered to represent a residue of native normal tissue. Exfoliation deposits appeared to stimulate the synthesis of collagen types I and IV at an early stage of the disease.