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Beneficial effect of sodium sucrose‐sulfate on the ocular surface of patients with severe KCS in primary Sjögren's syndrome
Author(s) -
Prause J. U.
Publication year - 1991
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1991.tb02015.x
Subject(s) - sucralfate , medicine , gastroenterology , adverse effect , rose bengal , chemistry , organic chemistry
Sucralfate (aluminium sucrose‐sulfate), a well known gastric mucosal protectant, has been tested topically on 22 patients (20 females and 2 males) suffering from primary Sjögren's syndrome. Median treatment period was 6 months (range 1–19 months). Statistically significant improvement in the ocular surface condition was found judged from the reduction in Rose‐Bengal score ( P ≤ 0.00005). The beneficial effect appeared within the first 1–4 months of treatment. No adverse side effects were encountered.