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The effect of oral metyrapone on aqueous humor dynamics in normal human eyes
Author(s) -
Mito Takezo,
Shiono Takashi,
Kimura Ryozo,
Tamai Makoto
Publication year - 1990
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1990.tb04792.x
Subject(s) - metyrapone , aqueous humor , endocrinology , medicine , chemistry , ophthalmology
We studied the possible influence of oral metyrapone tartrate (which inhibits the adrenal biosynthesis of cortisol) on the rate of aqueous humor flow in 9 eyes of 8 normal subjects by fluorophotometry. On the control day, the mean value of K 0 was 1.04 ± 0.32 min −1 × 10 −2 , where K 0 was the loss coefficient from the anterior chamber. On the metyrapone trial day, the mean value of K 0 was 0.63 ± 0.15 min −1 × 10 −2 . The mean difference in K 0 between the two periods was significant ( P < 0.005). These results indicated that systemic metyrapone administration decreases the rate of aqueous humor flow…