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Effects of long‐term chloroquine exposure on the phospholipid metabolism in retina and pigment epithelium of the mouse
Author(s) -
Hallberg Anders,
Naeser Peter,
Andersson Arne
Publication year - 1990
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1990.tb01892.x
Subject(s) - phospholipidosis , retinal pigment epithelium , chloroquine , phospholipid , epithelium , lipofuscin , pigment , retina , lysophosphatidylcholine , biology , microbiology and biotechnology , metabolism , chemistry , biochemistry , phosphatidylcholine , membrane , immunology , neuroscience , genetics , organic chemistry , malaria
The influence of 6 month's treatment of normal mice with chloroquine on neuroretina and retinal pigment epithelium has been investigated biochemically and morphologically. All classes of neuroretinal phospholipids, except lysophosphatidylcholine, showed increased 14 C‐glucose incorporation after chloroquine treatment. No metabolic changes were observed in the pigment epithelium after the chloroquine treatment. Morphological signs of phospholipidosis were only evident in the ganglion cells of the neuroretina. It is concluded that long‐term treatment with chloroquine does not affect pigment epithelium phospholipid metabolism but leads to morphological and biochemical signs of phospholipidosis in the neuroretina.