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Linkage relations of the locus for granular corneal dystrophy Groenouw type I with 35 polymorphic systems
Author(s) -
Møller H. U.,
Eiberg Hans,
Kruse Torben A.
Publication year - 1989
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1989.tb04410.x
Subject(s) - locus (genetics) , genetics , genetic linkage , biology , dystrophy , chromosome , corneal dystrophy , genetic linkage map , gene , gene mapping , cornea , neuroscience
The paper presents preliminary results of linkage relations of the lotus for granular corneal dystrophy Groenouw type I employing 35 classic genetic markers. Blood and saliva from 124 members of one family with this disorder were examined with the aim of localizing the disease to a certain chromosome. The highest lodscore was 1.04 in females at theta 0.00 to the system C1R, thus supplying a clue for continued gene‐mapping investigations on the short arm of chromosome No. 12.