Premium
Conjunctival keratinisation, an abnormal reaction to an ocular beta‐blocker
Author(s) -
Derous D.,
Keizer R. J. W.,
WolffRouendaal D.,
Soudijn W.
Publication year - 1989
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1989.tb01883.x
Subject(s) - practolol , retinoic acid , medicine , pharmacology , drug , beta blocker , chemistry , biochemistry , heart failure , propranolol , gene
Conjunctival leucoplakia was induced by the local beta‐blocker metipranolol in one case. Withdrawal of the drug and application of all‐trans retinoic acid ointment resulted in resolving of the keratinisation. A striking pharmacological resemblance is discovered between metipranolol and practolol. Metipranolol seems to be a less toxic phenol derivative of practolol. Nevertheless, it seems able to act as antigen.