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Serum beta‐2 microglobulin level in acute idiopathic anterior uveitis
Author(s) -
Sen D. K.,
Chilana J. S.,
Mathur M. D.,
Sarin G. S.
Publication year - 1989
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1989.tb00729.x
Subject(s) - medicine , beta 2 microglobulin , uveitis , anterior uveitis , beta (programming language) , disease , gastroenterology , renal function , immunology , computer science , programming language
Serum beta‐2 microglobulin levels were measured in 68 patients with acute idiopathic anterior uveitis and 51 healthy subjects by ELISA technique. The levels were found to be significantly increased in moderate and severe types of uveitis despite a normal renal glomerular function in all patients. The parameters remained unaltered in mild types. Serum beta‐2 microglobulin levels closely paralleled the severity of the disease. The increased beta‐2 microglobulin level in serum showed a significant fall to normal levels on clinical improvement. The data further strengthen the hypothesis that acute idiopathic anterior uveitis is an immune mediated disease. It is proposed that serum beta‐2 microglobulin may be considered as a reliable parameter of the degree of severity of acute idiopathic anterior uveitis, as well as representing a useful tool for the evaluation of drug efficacy, especially in intractable cases.