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Clinical trial of sustained‐release artificial tears in keratoconjunctivitis sicca and Sjögren's syndrome
Author(s) -
Lindahl Göran,
Calissendorff Berit,
Carle Berit
Publication year - 1988
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1988.tb08526.x
Subject(s) - keratoconjunctivitis sicca , artificial tears , medicine , tears , keratoconjunctivitis , schirmer test , adverse effect , sicca syndrome , ophthalmology , surgery , dermatology , dry eyes , disease
. The effect of sustained‐release artificial tear inserts on symptoms and signs of reduced tear production in keratoconjunctivitis sicca (KCS) was evaluated in an open clinical trial including 30 patients. A significant relief of sicca symptoms and a decrease in keratoconjunctival staining were seen in 10 patients fulfilling the study, whereas no significant effect on Schirmer test and tear break‐up‐time could be detected, neither in patients with pure KCS nor with KCS as a manifestation of Sjögren's syndrome. Twenty patients (67%) withdrew due to adverse effects, which were reported in total 80% of the patients. Absence of measurable tear secretion predicted treatment failure. Due to the frequent side effects, the artificial tear inserts cannot be recommended as a first line treatment in KCS patients.