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Plasmin in subretinal fluid
Author(s) -
Immonenm Ilkka J. R.,
Salonen EevaMarjatta,
Vaheri Antti I.,
Laatikainen Leila T.
Publication year - 1988
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1988.tb04055.x
Subject(s) - plasmin , proliferative vitreoretinopathy , retinal detachment , retina , ophthalmology , retinal pigment epithelium , extracellular matrix , retinal , medicine , extracellular , retinopathy , chemistry , posterior vitreous detachment , biology , biochemistry , endocrinology , enzyme , diabetes mellitus , neuroscience
. Proteolytic activity was studied in subretinal fluid from 56 eyes with rhegmatogenous retinal detachment without vitreous or subretinal hemorrhage. Active plasmin (1.0–15.2 μg/ml) was found in 33 eyes and plasmin‐inhibitor complexes in 3 eyes. Plasmin was detected more often in large detachments, but there was no clear correlation with the duration of the detachment or characteristics of the holes in the retina. It seems possible that plasmin in subretinal fluid may enhance release of cells from the pigment epithelium by degrading the extracellular matrix and contribute to the development of proliferative vitreoretinopathy.