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Comparison of topical timolol vs betaxolol on cardiopulmonary exercise performance in healthy volunteers
Author(s) -
Dickstein K.,
Hapnes R.,
Aarsland T.,
Kristianson K.,
Viksmoen L.
Publication year - 1988
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1988.tb04041.x
Subject(s) - timolol , betaxolol , medicine , heart rate , anesthesia , anaerobic exercise , oxygen pulse , vo2 max , intraocular pressure , cardiology , blood pressure , ophthalmology , physical therapy
. The effects of topical timolol vs betaxolol on cardiopulmonary exercise performance were studied in a randomised double‐masked fashion in 12 healthy male volunteers. Cardiopulmonary parameters were evaluated at the anaerobic threshold and at peak exercise. Intraocular pressure was determined before and after treatment by applanation tonometry. No differences were found in aerobic or peak exercise capacity. Maximal heart rate was slightly lower ( P ≶ 0.05) following treatment with timolol compared with betaxolol. However, a correspondingly higher oxygen pulse (oxygen uptake/heart rate) compensated for this reduction and resulted in no difference in peak performance. At physiological work levels, it was not possible to demonstrate any influence of topical, selective or non‐selective, beta‐adrenergic blockade on cardiopulmonary exercise performance in these healthy volunteers.