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Nerve fibers showing immunoreactivities for thyrosine hydroxylase and dopamine‐beta‐hydroxylase re‐appear in the guinea pig uvea after sympathectomy
Author(s) -
Lehtosalo J.,
Eränkö L.,
Palkama A.,
Uusitalo H.
Publication year - 1988
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1988.tb04034.x
Subject(s) - uvea , tyrosine hydroxylase , guinea pig , sympathectomy , catecholaminergic , ganglion , ciliary body , anatomy , denervation , endocrinology , catecholamine , biology , medicine , pathology , dopamine , ophthalmology , eye disease
. After sympathectomy we have studied the re‐appearence of nerve fibers showing catecholaminergic characteristics in the uvea of the guinea pig. Immunoreactivities for two catecholamine symthetizing enzymes, tyrosine hydroxylase (TH) and dopaminebeta‐hydroxylase (DBH), were used as markers. Both TH‐like and DBH‐like immunoreactive nerve fibers disappeared after the extirpation of ipsilateral superior cervical ganglion. In the choroid the TH‐like and DBH‐like immunoreactive nerve fibers re‐appeared within 2 weeks. In the iris and the ciliary body both of these types of immunoreactive nerve fibers re‐appeared 10 weeks after the denervation. The morphological appearence of these re‐appearing nerve fibers was not similar to those in the non‐denervated uvea.