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Predictive value of flow cytometric DNA‐analysis on fresh retinoblastoma tissue
Author(s) -
Winther J.,
Ehlers N.,
Jensen O. A.,
Overgaard J.,
Prause J. U.
Publication year - 1988
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1988.tb04016.x
Subject(s) - retinoblastoma , histopathology , pathology , dna , ploidy , biology , medicine , genetics , gene
. The cellular DNA content and the distribution of turnour cells in different phases of the cell cycles has been analysed in 8 consecutive enucleated eyes with retinoblastoma. All tumours had abnormal ploidy levels. The analysis did not reveal any specific pattern in 2 tumours which had metastasized compared to 6 local tumours. The flow cytometric analysis alone or in combination with histopathology appeared not to improve the classification of large retinoblastomas.