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Impairment of colour vision associated with amiodarone keratopathy
Author(s) -
Duff G. R.,
Fraser A. G.
Publication year - 1987
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1987.tb08490.x
Subject(s) - medicine , amiodarone , colour vision , ophthalmology , ptosis , atrial fibrillation , artificial intelligence , computer science
. Objective changes in colour vision have not been demonstrated previously in patients on long‐term amiodarone therapy, although the occurrence of blurring of vision and seeing coloured haloes around lights has been widely reported. In a masked study, colour vision was assessed in 15 patients who had been treated with amiodarone for 16–72 months. Subjects with extensive corneal microdeposits (Miller stage 3) had worse colour vision than subjects with mild or moderate corneal changes (Miller stages I and 2) ( P = 0.02), and higher serum concentrations of the metabolite desethlyamiodarone ( P = 0.008). The only subject with marked asymmetry of corneal changes had a long‐standing unilateral ptosis, suggesting that exposure to light might influence the development of corneal changes.