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The concentration of lysozyme and secretory IgA in tears from healthy persons with and without contact lens use
Author(s) -
Vinding Troels,
Eriksen Jens Sindberg,
Nielsen Niels Vesti
Publication year - 1987
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1987.tb08485.x
Subject(s) - lysozyme , contact lens , secretory iga , tears , lens (geology) , ophthalmology , medicine , antibody , immunology , chemistry , biology , biochemistry , paleontology
Abstract. A comparison of tear lysozyme and tear secretory IgA, determined by micropipette sampling and immunoassay technique, between 18 long‐term contact lens wearers (median age 35 years, median lysozyme concentration 1.93 g/l, median IgA concentration 0.72 g/l) and 42 non‐contact lens wearers (median age 41 years, median lysozyme concentration 2.21 g/l, median IgA concentration 2.42 g/l) disclosed a significant decrease ( P < 0.01) of secretory IgA in the contact lens group. The decrease of secretory IgA was associated ( P < 0.01) with the presence of deposits on lens surface. No differences in lysozyme concentration was found between the two groups ( P > 0.05). The duration of lens wear was 8.5 years in average ranging from 1 to 23 years. These findings of decreased secretory IgA might partly explain the fact that contact lens wearers are more exposed to infectious corneal and conjunctival complications than non‐contact lens wearers.