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Two year electrophysiology follow‐up in quinine amblyopia
Author(s) -
Moloney Jane B. M.,
Hillery Maureen,
Fenton Maurice
Publication year - 1987
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1987.tb07072.x
Subject(s) - quinine , electrophysiology , ganglion , ophthalmology , medicine , retina , visual acuity , evoked potential , electroretinography , audiology , anatomy , neuroscience , physiology , psychology , malaria , retinal , pathology
A 19‐year‐old girl presenting with quinine amblyopia had serial electrophysiology studies over a 2 year period. Visually evoked responses and the electro‐oculogram were abolished early. By 2 months the VER and visual acuity had returned to normal. The electro‐retinogram, initally mildly subnormal, became virtually abolished by 2 months. No recovery in cone function took place. Of the rods 50% regained function with normal latency by 1 year, but receptor sensitivity did not return to normal until 2 years after ingestion. The electro‐oculogram also recovered slowly over a 2 year period. This pattern suggest that quinine exerts a direct toxic effect on the cells of the outer retina and pigment epithelium, as well as on the ganglion cells.