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Centripetal movement of fluorescein dextrans in the cornea: relevance to arcus
Author(s) -
Green Keith,
Barge L. Raymond,
Cheeks Lisa,
Phillips Calbert I.
Publication year - 1987
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1987.tb07037.x
Subject(s) - sclera , cornea , fluorescein , sodium fluorescein , tracer , ophthalmology , chemistry , anatomy , medicine , optics , fluorescence , physics , nuclear physics
The centripetal movement of fluorescein and fluorescein‐labelled dextrans (4 to 150 kD) from sclera or cut edge of the cornea was determined in isolated rabbit corneas at 4 and 24 h. Corneas were divided into 5.5 mm diameter central core, inner 5.5 to 8 mm donut, 8 to 12 mm peripheral donut and, where applicable, scleral rim. For all molecules greater than sodium fluorescein (376 D) tracer concentrations in the 5.5 mm core and the 5.5 to 8 mm donut were equal. Without sclera rim, the more central portions of the cornea (5.5 mm core and 5.5 to 8 mm donut) had tracer concentrations equal to those of corneas‐with‐sclera for all tracers greater than 10 kD. The tracer concentrations in the central cornea were the same in the presence or absence of sclera. The data indicate a physiological barrier to the lateral diffusion of molecules greater than 10 kD between the peripheral and more central cornea.