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Suppression of experimental autoimmune uveitis in guinea‐pigs by inhibition of phospholipase A2
Author(s) -
Mahlberg Kaj,
Uusitalo Risto,
Uusitalo Hannu,
Palkama Arto,
Tallberg Thomas
Publication year - 1987
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1987.tb02621.x
Subject(s) - guinea pig , uveitis , adjuvant , myeloperoxidase , medicine , antigen , pharmacology , immunology , endocrinology , inflammation
Retinal S‐antigen mixed with complete Freund's adjuvant was used to induce experimental autoimmune uveitis (EAU) in guinea‐pigs. Guinea‐pigs receiving no treatment, was compared with test animals which received topically and systemically administered KLM‐583B, a phospholipase A 2 (PLA2) inhibitor, or subcutaneous (sub. cut) and topical corticosteroid treatment, as well as a test group which received cyclosporin A suc. cut. The best clinical suppression of EAU was obtained in the group treated suc. cut with KLM‐538B. Steroids also suppressed the inflammation in the eyes but was not as effective as KLM‐583B or cyclosporine A. PLA 2 activity in the aqueous humour and the myeloperoxidase (MPO) levels measured from iris‐ciliary body were signficantly lower in the groups treated suc. cut. with KLM‐583B or cyclosporin A. Guinea‐pigs treated suc. cut. with KLM‐583B and cyclosporin A had the lowest antiserum titres to retinal S‐antigen.