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Breakdown of the blood‐retinal barrier in multiple sclerosis measured by vitreous fluorophotometry
Author(s) -
Engell Tine,
Krogsaa Bent,
LundAndersen Henrik
Publication year - 1986
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1986.tb06977.x
Subject(s) - medicine , retinal , multiple sclerosis , retina , ophthalmology , blood–retinal barrier , permeability (electromagnetism) , chemistry , biology , endocrinology , neuroscience , immunology , biochemistry , membrane , diabetic retinopathy , diabetes mellitus
Periphlebitis retinae in multiple sclerosis appears as transitory cellular infiltrations around veins in an otherwise normal retina. Similar cellular infiltrations have been found around veins in the central nervous system. In the present study the blood‐retinal barrier has been investigated by vitreous fluorophotometry. Eight multiple sclerosis patients with actual periphlebitis retinae and 9 patients with previous but not active periphlebitis retinae were included in this study. Abnormal leakage of fluorescein was manifest in the group of multiple sclerosis patients with periphlebitis retinae. Permeability (1.8 ± 0.2 times 10 ‐7 cm/sec; mean ± SEM) but not in the control group as a whole permeability (1.3 ± 0.1 times 10 ‐7 cm/sec; mean ± SEM) compared to 17 normals (permeability 1.1 ± 0.005). It is thus concluded that breakdown of the blood‐retinal barrier may be transitory when connected with periphlebitis retinae in multiple sclerosis.