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Acute glucose‐derived osmotic stress in rabbit lenses
Author(s) -
Seland Johan H.,
Chylack Leo T.
Publication year - 1986
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1986.tb06968.x
Subject(s) - vacuolization , rabbit (cipher) , vacuole , lens fiber , lens (geology) , osmotic shock , nucleus , chemistry , osmotic concentration , anatomy , ophthalmology , biophysics , biology , cytoplasm , endocrinology , biochemistry , microbiology and biotechnology , medicine , paleontology , statistics , mathematics , gene
The morphological changes observed in rabbit lenses incubated without corpus vitreum in medium whose glucose concentration varied cyclically between normoglycaemia and hyperglycaemia were analyzed for the location of light scattering vacuoles. Minimal changes were seen in the epithelial cells, the external bow fibres and the lens nucleus, while maximal changes with vacuolization and damage were seen in the posterior part of the inner bow fibres. It was shown that the exchange of water takes place mainly across the posterior capsule. The susceptibility of this region in part may be due to the low aldose recuctase activity in this region of the lens.