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Angiotensin‐converting enzyme in sarcoid and chalazion granulomas of the conjunctiva
Author(s) -
Immonen I.,
Friberg K.,
GrönhagenRiska C.,
Willebrand E.,
Fyhrquist F.
Publication year - 1986
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1986.tb06965.x
Subject(s) - chalazion (fungus) , medicine , sarcoidosis , granuloma , pathology , eyelid , staining , conjunctiva , dermatology , surgery
Angiotensin‐converting enzyme (ACE) was studied immunohistochemically in conjunctival biopsies from 6 patients with systemic sarcoidosis, 4 patients with posterior non‐sarcoid uveitis and in specimens from 4 patients with chalazion of the eyelid. Specimens with sarcoid granulomas showed intense ACE‐positive immunoreactivity in epitheloid cells of the granuloma, whereas chalazion granulomas did not contain ACE‐immunoreactivity. There was no difference in staining patterns between specimens without granulomas. Thus immuno‐histochemical staining for ACE may be of help in differentiating conjunctival granulomatous tissue of a chalazion from sarcoid granuloma.