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The blood‐retinal barrier permeability to fluorescein in normal subjects and in juvenile diabetics without retinopathy
Author(s) -
Krogsaa Bent,
LundAndersen Henrik,
Mehlsen Jesper,
Sestoft Leif
Publication year - 1986
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1986.tb06896.x
Subject(s) - fluorescein , medicine , ophthalmology , retinal , juvenile , retinopathy , diabetic retinopathy , blood–retinal barrier , diabetes mellitus , endocrinology , biology , fluorescence , optics , physics , genetics
The blood‐retinal barrier permeability to fluorescein was determined in 20 eyes from 17 normal volunteers (mean age 31 years) and in 20 eyes from 19 juvenile diabetics without apparent retinopathy (mean age 35 years – mean duration of diabetes 6 years). The permeability was in normal subjects (1.1 ± 0.4) · 10 ‐7 cm/sec (mean ± 2 · SD) and in juvenile diabetics (1.1 ± 0.7) · 10 ‐7 cm/sec (mean ± 2 · SD). Thus a break‐down of the blood‐retinal barrier cannot be demonstrated as a very early and general phenomenon in the early course of the diabetic disease. The fluorescein diffusion coefficient in the vitreous body was determined and juvenile diabetics without apparent retinopathy showed a diffusion coefficient of (0.80 ± 0.25) · 10 ‐5 cm 2 /sec (mean ± 2 · SD), which was the same as in normals where the diffusion coefficient was (0.69 ± 0.46) · 10 ‐5 cm 2 /sec (mean ± 2 · SD).