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Timolol and cornea
Author(s) -
Olsen Erling Grøvold,
Davanger Martin
Publication year - 1986
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1986.tb00676.x
Subject(s) - timolol , cornea , ophthalmology , drug , corneal epithelium , medicine , aqueous humour , chemistry , pharmacology , aqueous humor , glaucoma
The influence of timolol on the corneal epithelium and endothelium was studied in organ culture. The cell morphology was not influenced by drug concentrations ≦ 690 μg/ml. Cell death was observed at 6900 μg/ml. Endothelial cell proliferation after an experimental injury was slowed down at a drug concentration of 690 μg/ml. Injurious effects were not observed at the drug concentrations found in the aqueous humour by use of ophthalmic eye solution in eyes with a normal cornea. However, it may be indicated to use eye drops with reduced concentration of timolol in conditions facilitating the resorbtion of the drug.