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The blood‐retinal barrier permeability to fluorescein in juvenile diabetics treated with continuous subcutaneous insulin infusion
Author(s) -
Krogsaa Bent,
LundAndersen Henrik,
Lauritzen Torsten,
Parving HansHenrik,
Christiansen Jens Sandahl
Publication year - 1985
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1985.tb06861.x
Subject(s) - liter , retinal , blood–retinal barrier , medicine , fluorescein , insulin , juvenile , permeability (electromagnetism) , diabetes mellitus , ophthalmology , diabetic retinopathy , anesthesia , endocrinology , chemistry , biology , biochemistry , physics , genetics , quantum mechanics , membrane , fluorescence
To determine possible quantitative changes of the blood‐retinal barrier permeability in juvenile diabetics treated with continuous subcutaneous insulin infusion (CSII), we studied seven patients (three females and four males, mean age 36 years) with a mean duration of the disease of 19 years. The pump treatment was continued for seven to eight days and during the treatment mean blood glucose level decreased to near‐normal values (before 13.7 mmol per liter ‐ during 6.2 mmol per liter). There was no changes in retinal appearance during treatment. Determination of the blood‐retinal barrier permeability showed no quantitative changes during the one week treatment with CSII (mean permeability before 7.6 10 ÷7 cm/sec ‐ mean permeability during 7.8 10 ÷7 cm/sec). In order to quantitate possible long‐term reversibility of break‐down of the blood‐retinal barrier we have design to extend the treatment period.