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Some problems involved in employing the ERG c‐wave in pharmacological experiments: conditioning in pigmented rabbits
Author(s) -
Naoi Nobuhisa,
Kim SiYeol,
Honda Yoshihito
Publication year - 1985
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1985.tb05246.x
Subject(s) - erg , retinal pigment epithelium , electroretinography , amplitude , retina , retinal , chemistry , medicine , optics , ophthalmology , biology , physics
. The large inter‐ and intra‐individual variations in ERG c‐waves have prevented the application of the component in pharmacological experiments on the retinal pigment epithelial function. We examined some of the problems involved in employing the c‐wave in pharmacological experiments using rabbit retinas.1) Under our experimental conditions, the c‐wave amplitudes in some rabbits reached equilibrium under intermittent stimuli, while in others they increased with time and did not reach a constant level in 3 h. 2) The c‐wave amplitudes of the right and left eyes were similar, indicating that the contralateral eye can be used as a control during local administration of drugs. 3) The c‐wave amplitude under 50 lux light had smaller inter‐individual variations than that in the dark. This may be a useful indicator of the retinal pigment epithelium function when drugs are administered systemically.