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A comparison between iris‐ciliary body concentration and receptor affinity of timolol
Author(s) -
Urtti Arto,
Salminen Lotta
Publication year - 1985
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1985.tb05207.x
Subject(s) - timolol , ciliary body , iris (biosensor) , ophthalmology , intraocular pressure , drug , medicine , pharmacology , chemistry , computer security , computer science , biometrics
. Topical unilateral application of timolol reduces the IOP (intraocular pressure) of both the treated and the untreated eye. For this reason, a central mechanism of action, in addition to the local one, has been suggested for the reduction of IOP by this drug. In this study timolol concentrations in the iris‐cliliary body of the treated and untreated rabbit eyes were compared with pharmacologically active in vitro timolol concentrations. The drug concentration in the untreated eye too was found to be high enough to exert a local action.