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Biochemical studies of normal and keratoconus corneas
Author(s) -
Oxlund Hans,
Simonsen Anders Hjorth
Publication year - 1985
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1985.tb01578.x
Subject(s) - keratoconus , ophthalmology , cornea , chemistry , mechanical strength , medicine , materials science , composite material
Abstract. Keratoconus corneas are characterized by a reduced mechanical stability. The mechanical strength depends primarily on the collagen. In the present study the cross‐linking pattern is analysed because it is important for the mechanical properties; an analysis of the aminoacids of the collagen is included. Surprisingly, we did not find any change in the cross‐linking pattern of collagen from keratoconus corneas compared to normal corneas. Neither did we find any difference in the composition of aminoacids of the collagens. Thus no alteration was found in the molecular structure which could explain the marked reduction in the mechanical stability of keratoconus corneas.