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Prostaglandin E 2 level in tears during postoperative inflammation of the eye
Author(s) -
Gluud B. S.,
Jensen O. L.,
Krogh E.,
Birgens H. S.
Publication year - 1985
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1985.tb01547.x
Subject(s) - tears , medicine , conjunctiva , inflammation , prostaglandin e2 , ophthalmology , prostaglandin , bacteriology , positive correlation , secretion , surgery , immunology , biology , bacteria , genetics
. The concentration of prostaglandin E 2 (PGE 2 ) in tears was measured by a radio immuno assay technique in 25 persons before cataract extraction and during the post‐operative period. In addition we studied the clinical signs of inflammation, the tear secretion rate, the content of polymorphonuclear leucocytes (PMNs) in tears, the bacteriology of the conjunctival sac and the central corneal thickness (CCT) during this period. We found pre‐operative median level of PGE 2 of 82 pg/ml and on the first post‐operative day a significant rise in PGE 2 concentration despite increased tearing. There was a tendency towards further gradual increase in PGE 2 concentration until the 5th day and thereafter a decline to pre‐operative level 12 days after surgery. The conjunctiva is proposed as a possible source of the PGE 2 in tears. No significant correlation could be demonstrated between PGE 2 levels and clinical signs of inflammation, CCT, PMN level, bacteriology or tear secretion rate.