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EFFECT OF PROSTAGLANDIN‐INHIBITOR NAPROXEN ON THE CORNEAL SWELLING RESPONSE TO HYDROGEL CONTACT LENS WEAR
Author(s) -
EFRON NATHAN,
HOLDEN BRIEN A.,
VANNAS ANTTI
Publication year - 1984
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1984.tb05802.x
Subject(s) - naproxen , contact lens , medicine , cornea , swelling , ophthalmology , prostaglandin e2 , placebo , effects of long term contact lens wear on the cornea , prostaglandin , edema , inflammatory response , pharmacology , inflammation , surgery , pathology , alternative medicine
Previous studies have demonstrated that the prostaglandin‐inhibitor naproxen can reduce post‐surgical corneal oedema, which is largely due to an inflammatory process. To determine whether there is an inflammatory component in the oedematous response of the cornea to contact lens wear, we conducted a randomized, double‐masked, placebo‐controlled study on the effect of naproxen on contact lens‐induced corneal swelling. This drug did not have a significant effect, suggesting that prostaglandins are not involved in the hypoxic oedema response. The discrepancy between the effect of naproxen on lens‐ and surgically‐induced corneal oedema can be attributed to the different aetiologies of these oedema responses.