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CORNEAL BURNS: A QUANTITATIVE COMPARISON OF ACID AND BASE
Author(s) -
FLYNN W. J.,
MAUGER T. F.,
HILL R. M.
Publication year - 1984
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1984.tb03966.x
Subject(s) - base (topology) , medicine , ophthalmology , optometry , mathematics , mathematical analysis
A quantitative comparison is made of the effects of two of the most completely dissociating representatives from the pH spectrum, sodium hydroxide and hydrochloric acid, on oxygen uptake by the corneal epithelium. Based on initial observations, a 6 to 1 time ratio in the exposure period (acid, 60 seconds; base, 10 seconds) was found necessary to localize and define similiar aerobic effects by the 2 agents on their concentration scales. A further dosage adjustment factor was required, a 5/1 concentration ratio of acid to base, to achieve near parity of the major depressive thresholds of those 2 agents, as well as to illustrate in the resulting graphical model sevel unique features of each in their aerobic effects on corneal tissue at lower concentrations.