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DIABETES MELLITUS AND DIABETIC RETINOPATHY
Author(s) -
SAARI K. M.
Publication year - 1984
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1984.tb03078.x
Subject(s) - diabetes mellitus , medicine , human leukocyte antigen , diabetic retinopathy , retinopathy , disease , immunology , endocrinology , antigen
HLA studies showed that there is an increased relative risk of developing insulin‐dependent diabetes mellitus, irrespective of age of onset, in subjects who are HLA‐Dw3 or HLA‐DR3 positive, with secondary associations with A1, B8 or B18, and in subjects who are Dw4 or DR4 positive, with secondary associations with A2, B15, B40 and Cw3. Subjects who are HLA‐Dw2 or HLA‐DR2 positive, with secondary association with A3 and B7, have a significantly reduced risk of developing the disease. No association has been confirmed in independent studies between HLA and noninsulin‐dependent diabetes mellitus. There is no confirmed evidence that HLA would be involved in the susceptibility to retinopathy once diabetes has developed.