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HLA SYSTEM AND MULTIPLE SCLEROSIS
Author(s) -
SAARI K. M.
Publication year - 1984
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1984.tb03075.x
Subject(s) - multiple sclerosis , human leukocyte antigen , linkage disequilibrium , optic neuritis , medicine , population , immunology , haplotype , biology , allele , genetics , antigen , environmental health , gene
Multiple sclerosis (MS) occurs most frequently in northern and central Europe, the north of the United States, and Canada; it is more rare in China and Japan. Population studies showed association between HLA‐A3, B7, Dw2, and DR2 with MS. There was a close association of MS with HLA‐Dw2 and DR2, and the increased frequencies of A3 and B7 were secondary to linkage disequilibrium of B7 with Dw2, and of A3 with B7 in Caucasians. Black American MS patients showed a slight association with Dw2. In Japan, there was an association between MS and Dw6. The HLA pattern in optic neuritis (ON) patients failed between that of MS patients and healthy controls; ON only progressed to MS if the immunogenetic terrain was favourable.