Premium
THE HLA SYSTEM
Author(s) -
OHNO SHIGEAKI
Publication year - 1984
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1984.tb03060.x
Subject(s) - human leukocyte antigen , linkage disequilibrium , biology , locus (genetics) , genetics , histocompatibility , antigen , immunology , immune system , major histocompatibility complex , hla a , gene , haplotype , allele
The HLA system is a major histocompatibility system in man, and the HLA antigens are controlled by a complex genetic locus on the autosomal chromosome 5. There exist five HLA loci, HLA‐A, HLA‐C, HLA‐B, HLA‐D and HLA‐DR. HLA‐A, B, C and DR antigens are detected serologically, and HLA‐D antigens by a mixed lymphocyte culture. Polymorphism, racial differences and linkage disequilibrium are three important characteristics of the HLA system. HLA system has various significant biological functions, and HLA genes have a marked effect on the immune reponse and susceptibility to diseases.